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Terlipressin Acetate

Terlipressin Acetate

Publish Time: 2017-03-27

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Industry: Chemicals»Organic Intermediate

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Product Details


Product Name Terlipressin Acetate


Sequence


Cas No. 14636-12-5


Molecular Formula C52H74N16O15S2


Molecular Weight 1227.37


Purity (HPLC) 98.0%min.


Appearance? White powder


Single Impurity (HPLC)? 1.0%max


Amino Acid Composition? ±10% of theoretical


Peptide Content (N%) ?≥80.0%


Water Content(Karl Fischer)? ≤10.0%


Specific Rotation (20/D) -95.0~-105.0°(c=1 1%HAc)


Acetate Content (HPIC) ≤15.0%


MS(ESI) Consistent


Mass Balance? 95.0~105.0%






Description:



Terlipressin (trade names Teripress by New Medicon Pharma and Glypressin by Ferring Pharmaceuticals) is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.


Indications for use include norepinephrine-resistant septic shock and hepatorenal syndrome. In addition, it is used to treat bleeding esophageal varices.


Between the patients with cirrhosis of the liver into the portal circulation of each vein and venous congestion can occur in vascular anastomosis, portal vein pressure rise phenomenon. The most frequently appeared in the azygos vein anastomosis with lower esophageal varices, instant tube.



Application:



This product is pressurized prodrug hormone, vasopressin glycyl in injection into the blood after enzymatic hydrolysis in the molecule is produced a continuous low level. The portal venous pressure it generates the desired effect, but the changes of arterial blood pressure than the use of vasopressin after much smaller, and the blood of a few do not increase the fibrinolytic. Push once its role can be maintained for about 4 ~ 6h.

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