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Granzyme B from Mouse, Recombinant

Granzyme B from Mouse, Recombinant

Publish Time: 2016-01-13

Region: United States»

Industry: Chemicals»Vitamins, Amino Acids And Coenzymes

Keywords: recombinant Granzyme B from Mouse  Recombinant 

Creative Enzymes

Contact:Lisa Clara
Member type:Corporate Member
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Product Details

Numbers NATE-0333
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Specifications loiszy@hotmail
Product Code loiszy@hotmail
Place of Origin USA

Granzyme B, a 247 amino acid polypeptide, contains a leader sequence, which is cleaved by a signal peptidase and a two amino acid prodomain, which is cleaved by the lysosomal cysteine protease DPPI. The recombinant granzyme B is expressed in Pichia pastoris as the mature form and appears on SDS-PAGE as a triplet (~34, 32, and 30 kDa) due to three different glycosylations. Granzyme B, a serine protease, is the most prominent granzyme in a family of 11 found in the cytotoxic granules. The granzymes enter the target cell with the assistance of perforin, a critical molecule of the cytotoxic granules. In the target cell, the granzymes act on specific substrates involved with the cell death via apoptosis.

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